CATH Classification

Domain Context

CATH Clusters

Superfamily Type I PLP-dependent aspartate aminotransferase-like (Major domain)
Functional Family

Enzyme Information

4.1.1.15
Glutamate decarboxylase.
based on mapping to UniProt Q99259
L-glutamate = 4-aminobutanoate + CO(2).
-!- The brain enzyme also acts on L-cysteate, 3-sulfino-L-alanine and L-aspartate.

UniProtKB Entries (1)

Q99259
DCE1_HUMAN
Homo sapiens
Glutamate decarboxylase 1

PDB Structure

PDB 2OKJ
External Links
Method X-RAY DIFFRACTION
Organism Saccharomyces
Primary Citation
GABA production by glutamic acid decarboxylase is regulated by a dynamic catalytic loop.
Fenalti, G., Law, R.H.P., Buckle, A.M., Langendorf, C., Tuck, K., Rosado, C.J., Faux, N.G., Mahmood, K., Hampe, C.S., Banga, J.P., Wilce, M., Schmidberger, J., Rossjohn, J., El-Kabbani, O., Pike, R.N., Smith, A.I., Mackay, I.R., Rowley, M.J., Whisstock, J.C.
Nat.Struct.Mol.Biol.