CATH Classification

Domain Context

CATH Clusters

Superfamily Dihydropteroate synthase-like
Functional Family 5-methyltetrahydrofolate:corrinoid/iron-sulfur protein co-methyltransferase

Enzyme Information

2.1.1.258
5-methyltetrahydrofolate:corrinoid/iron-sulfur protein Co-methyltransferase.
based on mapping to UniProt Q46389
A [methyl-Co(III) corrinoid Fe-S protein] + tetrahydrofolate = a [Co(I) corrinoid Fe-S protein] + 5-methyltetrahydrofolate.
-!- Catalyzes the transfer of a methyl group from the N(5) group of methyltetrahydrofolate to the 5-methoxybenzimidazolylcobamide cofactor of a corrinoid/Fe-S protein. -!- Involved, together with EC 1.2.7.4 and EC 2.3.1.169, in the reductive acetyl coenzyme A (Wood-Ljungdahl) pathway of autotrophic carbon fixation in various bacteria and archaea.

UniProtKB Entries (1)

Q46389
ACSE_MOOTH
Moorella thermoacetica
5-methyltetrahydrofolate:corrinoid/iron-sulfur protein co-methyltransferase

PDB Structure

PDB 2OGY
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structural and kinetic evidence for an extended hydrogen-bonding network in catalysis of methyl group transfer. Role of an active site asparagine residue in activation of methyl transfer by methyltransferases.
Doukov, T.I., Hemmi, H., Drennan, C.L., Ragsdale, S.W.
J.Biol.Chem.