CATH Classification

Domain Context

CATH Clusters

Superfamily Trypsin-like serine proteases
Functional Family complement C2 isoform X1

Enzyme Information

3.4.21.43
Classical-complement-pathway C3/C5 convertase.
based on mapping to UniProt Q5JP69
Selective cleavage of Arg-|-Ser bond in complement component C3 alpha- chain to form C3a and C3b, and Arg-|-Xaa bond in complement component C5 alpha-chain to form C5a and C5b.
-!- A complex of complement fragments C4b, C2a and C2b. -!- Belongs to peptidase family S1. -!- Formerly EC 3.4.21.44.

UniProtKB Entries (1)

Q5JP69
Q5JP69_HUMAN
Homo sapiens
C2

PDB Structure

PDB 2ODQ
External Links
Method X-RAY DIFFRACTION
Organism Trichoplusia
Primary Citation
The crystal structure of c2a, the catalytic fragment of classical pathway c3 and c5 convertase of human complement.
Krishnan, V., Xu, Y., Macon, K., Volanakis, J.E., Narayana, S.V.
J.Mol.Biol.