CATH Classification

Domain Context

CATH Clusters

Superfamily Ribonuclease H-like superfamily/Ribonuclease H
Functional Family Three prime repair exonuclease 1

Enzyme Information

3.1.11.2
Exodeoxyribonuclease III.
based on mapping to UniProt Q91XB0
Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates.
-!- Preference for double-stranded DNA. -!- Has endonucleolytic activity near apurinic sites on DNA. -!- Similar enzyme: Haemophilus influenzae exonuclease. -!- Formerly EC 3.1.4.27.

UniProtKB Entries (1)

Q91XB0
TREX1_MOUSE
Mus musculus
Three-prime repair exonuclease 1

PDB Structure

PDB 2OA8
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
The Crystal Structure of TREX1 Explains the 3' Nucleotide Specificity and Reveals a Polyproline II Helix for Protein Partnering.
de Silva, U., Choudhury, S., Bailey, S.L., Harvey, S., Perrino, F.W., Hollis, T.
J.Biol.Chem.