CATH Domain 2m2wA02

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.210	Beta Polymerase; domain 3
	3.30.210.10	DNA polymerase, thumb domain

Domain Context

CATH Clusters

Superfamily	DNA polymerase, thumb domain
Functional Family	Repair DNA polymerase X

Enzyme Information

2.7.7.7

DNA-directed DNA polymerase.

based on mapping to UniProt P42494

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).

-!- Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. -!- Cannot initiate a chain de novo. -!- Requires a primer which may be DNA or RNA. -!- See also EC 2.7.7.49.

UniProtKB Entries (1)

P42494

DPOLX_ASFB7

African swine fever virus BA71V

Repair DNA polymerase X

PDB Structure

PDB	2M2W
External Links	PDBSum Proteopedia
Method	SOLUTION NMR
Organism
Primary Citation	How a low-fidelity DNA polymerase chooses non-Watson-Crick from Watson-Crick incorporation. Wu, W.J., Su, M.I., Wu, J.L., Kumar, S., Lim, L.H., Wang, C.W., Nelissen, F.H., Chen, M.C., Doreleijers, J.F., Wijmenga, S.S., Tsai, M.D. J.Am.Chem.Soc.