CATH Classification

Domain Context

CATH Clusters

Superfamily Bromodomain-like
Functional Family Histone acetyltransferase p300

Enzyme Information

2.3.1.48
Histone acetyltransferase.
based on mapping to UniProt Q92793
Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine.
-!- A group of enzymes acetylating histones. -!- Several of the enzymes can also acetylate lysines in other proteins.

UniProtKB Entries (1)

Q92793
CBP_HUMAN
Homo sapiens
CREB-binding protein

PDB Structure

PDB 2L85
External Links
Method SOLUTION NMR
Organism
Primary Citation
A Small Molecule Binding to the Coactivator CREB-Binding Protein Blocks Apoptosis in Cardiomyocytes.
Borah, J.C., Mujtaba, S., Karakikes, I., Zeng, L., Muller, M., Patel, J., Moshkina, N., Morohashi, K., Zhang, W., Gerona-Navarro, G., Hajjar, R.J., Zhou, M.M.
Chem.Biol.