CATH Classification

Domain Context

CATH Clusters

Superfamily 3.40.50.2300
Functional Family

Enzyme Information

1.20.4.1
Arsenate reductase (glutaredoxin).
based on mapping to UniProt P74313
Arsenate + glutaredoxin = arsenite + glutaredoxin disulfide + H(2)O.
-!- A molybdoenzyme. -!- The enzyme is part of a system for detoxifying arsenate. -!- Although the arsenite formed is more toxic than arsenate, it can be extruded from some bacteria by EC 7.3.2.7; in other organisms, arsenite can be methylated by EC 2.1.1.137 in a pathway that produces non-toxic organoarsenical compounds (cf. EC 1.20.4.4). -!- Formerly EC 1.97.1.5.
3.1.3.48
Protein-tyrosine-phosphatase.
based on mapping to UniProt P74313
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
-!- Dephosphorylates O-phosphotyrosine groups in phosphoproteins, such as the products of EC 2.7.10.2.

UniProtKB Entries (1)

P74313
ARSC_SYNY3
Synechocystis sp. PCC 6803 substr. Kazusa
Glutaredoxin arsenate reductase

PDB Structure

PDB 2L19
External Links
Method SOLUTION NMR
Organism
Primary Citation
(1)H, (13)C and (15)N resonance assignments of the arsenate reductase from Synechocystis sp. strain PCC 6803
Yu, C., Xia, B., Jin, C.
Biomol.Nmr Assign.