CATH Classification

Domain Context

CATH Clusters

Superfamily 2.40.128.20
Functional Family Prostaglandin-H2 D-isomerase

Enzyme Information

5.3.99.2
Prostaglandin-D synthase.
based on mapping to UniProt O09114
(5Z,13E,15S)-9-alpha,11-alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E,15S)-9-alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate.
-!- Brings about the opening of the epidioxy bridge.

UniProtKB Entries (1)

O09114
PTGDS_MOUSE
Mus musculus
Prostaglandin-H2 D-isomerase

PDB Structure

PDB 2KTD
External Links
Method SOLUTION NMR
Organism
Primary Citation
Solution Structure of Lipocalin-type Prostaglandin D synthase / Substrate analog complex reveals Open-Closed Conformational Change required for Substrate Recognition
Shimamoto, S., Maruo, H., Yoshida, T., Inui, T., Miyamoto, Y., Kobayashi, Y., Tsurumura, T., Aritake, K., Urade, Y., Ohkubo, T.
To be Published