CATH Classification

Domain Context

CATH Clusters

Superfamily 3.10.50.40
Functional Family

Enzyme Information

5.2.1.8
Peptidylprolyl isomerase.
based on mapping to UniProt O25748
Peptidylproline (omega=180) = peptidylproline (omega=0).
-!- The first type of this enzyme found proved to be the protein cyclophilin, which binds the immunosuppressant cyclosporin A. -!- Other distinct families of the enzyme exist, one being FK-506 binding proteins (FKBP) and another that includes parvulin from Escherichia coli. -!- The three families are structurally unrelated and can be distinguished by being inhibited by cyclosporin A, FK-506 and 5-hydroxy-1,4-naphthoquinone, respectively.

UniProtKB Entries (1)

O25748
SLYD_HELPY
Helicobacter pylori 26695
FKBP-type peptidyl-prolyl cis-trans isomerase SlyD

PDB Structure

PDB 2KR7
External Links
Method SOLUTION NMR
Organism
Primary Citation
solution structure of Helicobacter pylori SlyD
Cheng, T., Li, H., Xia, W., Sze, K., Sun, H.
To be Published