CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.20 | Up-down Bundle |
|
1.20.58 | Methane Monooxygenase Hydroxylase; Chain G, domain 1 |
|
1.20.58.80 | Phosphotransferase system, lactose/cellobiose-type IIA subunit |
Domain Context
CATH Clusters
| Superfamily | Phosphotransferase system, lactose/cellobiose-type IIA subunit |
| Functional Family | Vacuolar protein sorting-associated protein 4A |
Enzyme Information
| 3.6.4.6 |
Vesicle-fusing ATPase.
based on mapping to UniProt Q9UN37
ATP + H(2)O = ADP + phosphate.
-!- A large family of ATP-hydrolyzing enzymes involved in the heterotypic fusion of membrane vesicles with target membranes and the homotypic fusion of various membrane compartments. -!- They belong to the AAA-type (ATPase associated with a variety of cell activities) ATPase superfamily. -!- They include peroxin, which apparently is involved in Zellweger's syndrome.
|
UniProtKB Entries (1)
| Q9UN37 |
VPS4A_HUMAN
Homo sapiens
Vacuolar protein sorting-associated protein 4A
|
PDB Structure
| PDB | 2K3W |
| External Links | |
| Method | SOLUTION NMR |
| Organism | |
| Primary Citation |
Two distinct modes of ESCRT-III recognition are required for VPS4 functions in lysosomal protein targeting and HIV-1 budding
Dev.Cell
|