CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.30 | 2-Layer Sandwich |
|
3.30.450 | Beta-Lactamase |
|
3.30.450.40 | GAF domain |
Domain Context
CATH Clusters
| Superfamily | 3.30.450.40 |
| Functional Family | Phosphodiesterase |
Enzyme Information
| 3.1.4.35 |
3',5'-cyclic-GMP phosphodiesterase.
based on mapping to UniProt Q8CG03
Guanosine 3',5'-cyclic phosphate + H(2)O = guanosine 5'-phosphate.
|
UniProtKB Entries (1)
| Q8CG03 |
PDE5A_MOUSE
Mus musculus
CGMP-specific 3',5'-cyclic phosphodiesterase
|
PDB Structure
| PDB | 2K31 |
| External Links | |
| Method | SOLUTION NMR |
| Organism | |
| Primary Citation |
Solution Structure of the cGMP Binding GAF Domain from Phosphodiesterase 5: Insights into Nucleotide Selectivity, Dimerization, and cGMP-Dependent Conformational Change.
J.Biol.Chem.
|