CATH Classification

Domain Context

CATH Clusters

Superfamily 6-Phosphogluconate Dehydrogenase, domain 3
Functional Family 6-phosphogluconate dehydrogenase, decarboxylating

Enzyme Information

1.1.1.44
Phosphogluconate dehydrogenase (NADP(+)-dependent, decarboxylating).
based on mapping to UniProt P96789
6-phospho-D-gluconate + NADP(+) = D-ribulose 5-phosphate + CO(2) + NADPH.
-!- The enzyme participates in the oxidative branch of the pentose phosphate pathway, whose main purpose is to produce NADPH and pentose for biosynthetic reactions. -!- Highly specific for NADP(+). -!- Cf. EC 1.1.1.343.

UniProtKB Entries (1)

P96789
6PGD_LACLM
Lactococcus lactis subsp. cremoris MG1363
6-phosphogluconate dehydrogenase, decarboxylating

PDB Structure

PDB 2IYP
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal Structures of a Bacterial 6-Phosphogluconate Dehydrogenase Reveal Aspects of Specificity, Mechanism and Mode of Inhibition by Analogues of High-Energy Reaction Intermediates.
Sundaramoorthy, R., Iulek, J., Barrett, M.P., Bidet, O., Ruda, G.F., Gilbert, I.H., Hunter, W.N.
FEBS J.