CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
2 | Mainly Beta |
|
2.60 | Sandwich |
|
2.60.120 | Jelly Rolls |
|
2.60.120.590 | Alpha-ketoglutarate-dependent dioxygenase AlkB-like |
Domain Context
CATH Clusters
| Superfamily | Alpha-ketoglutarate-dependent dioxygenase AlkB-like |
| Functional Family | alpha-ketoglutarate-dependent dioxygenase alkB homolog 3 |
Enzyme Information
| 1.14.11.54 |
mRNA N(1)-methyladenine demethylase.
based on mapping to UniProt Q96Q83
N(1)-methyladenine in mRNA + 2-oxoglutarate + O(2) = adenine in mRNA + formaldehyde + succinate + CO(2).
-!- Catalyzes oxidative demethylation of mRNA N(1)-methyladenine. -!- The enzyme is also involved in alkylation repair in DNA.
|
UniProtKB Entries (1)
| Q96Q83 |
ALKB3_HUMAN
Homo sapiens
Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3
|
PDB Structure
| PDB | 2IUW |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Human Abh3 Structure and Key Residues for Oxidative Demethylation to Reverse DNA/RNA Damage.
Embo J.
|