CATH Classification

Domain Context

CATH Clusters

Superfamily 3.40.50.970
Functional Family Acetolactate synthase

Enzyme Information

2.5.1.66
N(2)-(2-carboxyethyl)arginine synthase.
based on mapping to UniProt Q9LCV9
D-glyceraldehyde 3-phosphate + L-arginine = N(2)-(2-carboxyethyl)-L- arginine + phosphate.
-!- Requires thiamine diphosphate and catalyzes the first step in the clavulanic-acid biosynthesis pathway. -!- The 2-hydroxy-3-oxo group transferred from glyceraldehyde 3-phosphate is isomerized during transfer to form the 2-carboxyethyl group.

UniProtKB Entries (1)

Q9LCV9
CEAS_STRCL
Streptomyces clavuligerus
N(2)-(2-carboxyethyl)arginine synthase

PDB Structure

PDB 2IHT
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structural and mechanistic studies on N(2)-(2-carboxyethyl)arginine synthase.
Caines, M.E., Sorensen, J.L., Schofield, C.J.
Biochem.Biophys.Res.Commun.