CATH Classification

Domain Context

CATH Clusters

Superfamily P-loop containing nucleotide triphosphate hydrolases
Functional Family Polynucleotide kinase

Enzyme Information

2.7.1.78
Polynucleotide 5'-hydroxyl-kinase.
based on mapping to UniProt P06855
ATP + 5'-dephospho-DNA = ADP + 5'-phospho-DNA.
-!- Also acts on 5'-dephospho-RNA 3'-mononucleotides.
3.1.3.34
Deoxynucleotide 3'-phosphatase.
based on mapping to UniProt P06855
A deoxyribonucleoside 3'-phosphate + H(2)O = a deoxyribonucleoside + phosphate.
-!- Also catalyzes the selective removal of 3'-phosphate groups from DNA and oligodeoxyribonucleotides. -!- Induced in Escherichia coli by T-even phages.

UniProtKB Entries (1)

P06855
KIPN_BPT4
Escherichia virus T4
Polynucleotide kinase

PDB Structure

PDB 2IA5
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structure-function analysis of the 3' phosphatase component of T4 polynucleotide kinase/phosphatase.
Zhu, H., Smith, P., Wang, L.K., Shuman, S.
Virology