CATH Classification

Domain Context

CATH Clusters

Superfamily Beta Polymerase, domain 2
Functional Family DNA polymerase beta

Enzyme Information

2.7.7.7
DNA-directed DNA polymerase.
based on mapping to UniProt P06746
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
-!- Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. -!- Cannot initiate a chain de novo. -!- Requires a primer which may be DNA or RNA. -!- See also EC 2.7.7.49.
4.2.99.-
Other carbon-oxygen lyases.
based on mapping to UniProt P06746

UniProtKB Entries (1)

P06746
DPOLB_HUMAN
Homo sapiens
DNA polymerase beta

PDB Structure

PDB 2I9G
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structure of DNA polymerase beta with a benzo[c]phenanthrene diol epoxide-adducted template exhibits mutagenic features.
Batra, V.K., Shock, D.D., Prasad, R., Beard, W.A., Hou, E.W., Pedersen, L.C., Sayer, J.M., Yagi, H., Kumar, S., Jerina, D.M., Wilson, S.H.
Proc.Natl.Acad.Sci.Usa