CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.1450 | HybD-like |
Domain Context
CATH Clusters
| Superfamily | HybD-like |
| Functional Family | Hydrogenase 3 maturation endopeptidase HyCI |
Enzyme Information
| 3.4.23.51 |
HycI peptidase.
based on mapping to UniProt P0AEV9
This enzyme specifically removes a 32-amino acid peptide from the C-terminus of the precursor of the large subunit of E.coli hydrogenase 3 by cleavage at the C-terminal side of Arg-537.
-!- The reaction requires nickel to be bound to the precursor of the large subunit of hydrogenase 3. -!- The endopeptidase uses the metal in the large subunit of [NiFe]- hydrogenases as a recognition motif. -!- Belongs to peptidase family A31.
|
UniProtKB Entries (1)
| P0AEV9 |
HYCI_ECOLI
Escherichia coli K-12
Hydrogenase 3 maturation protease
|
PDB Structure
| PDB | 2I8L |
| External Links | |
| Method | SOLUTION NMR |
| Organism | Escherichia |
| Primary Citation |
Solution structure and backbone dynamics of an endopeptidase HycI from Escherichia coli: implications for mechanism of the [NiFe] hydrogenase maturation
J.Biol.Chem.
|