CATH Classification

Domain Context

CATH Clusters

Superfamily 7,8-dihydroneopterin aldolase (MptD)
Functional Family

Enzyme Information

4.1.2.25
Dihydroneopterin aldolase.
based on mapping to UniProt Q6L2J9
7,8-dihydroneopterin = 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde.
-!- The enzyme participates in folate (in bacteria, plants and fungi) and methanopterin (in archaea) biosynthesis. -!- The enzymes from the bacterium Escherichia coli and the plant Arabidopsis thaliana also catalyze the epimerisation of the 2' hydroxy-group (EC 5.1.99.8). -!- The enzyme from the bacterium Mycobacterium tuberculosis is trifunctional and also catalyzes EC 5.1.99.8 and EC 1.13.11.81. -!- The enzyme from the yeast Saccharomyces cerevisiae also catalyzes the two subsequent steps in the folate biosynthesis pathway - EC 2.7.6.3 and EC 2.5.1.15.

UniProtKB Entries (1)

Q6L2J9
MPTD_PICTO
Picrophilus torridus DSM 9790
Dihydroneopterin aldolase

PDB Structure

PDB 2I52
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structure of hypothetical protein PTO0218 from Picrophilus torridus
Ramagopal, U.A., Gilmore, J., Toro, R., Bain, K.T., McKenzie, C., Reyes, C., Sauder, J.M., Burley, S.K., Almo, S.C.
To be Published