CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphorylase Kinase; domain 1
Functional Family Tyrosine-protein kinase

Enzyme Information

2.7.10.2
Non-specific protein-tyrosine kinase.
based on mapping to UniProt P00520
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain. -!- In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P00520
ABL1_MOUSE
Mus musculus
Tyrosine-protein kinase ABL1

PDB Structure

PDB 2HZN
External Links
Method X-RAY DIFFRACTION
Organism Spodoptera
Primary Citation
Structural biology contributions to the discovery of drugs to treat chronic myelogenous leukaemia.
Cowan-Jacob, S.W., Fendrich, G., Floersheimer, A., Furet, P., Liebetanz, J., Rummel, G., Rheinberger, P., Centeleghe, M., Fabbro, D., Manley, P.W.
ACTA CRYSTALLOGR.,SECT.D