CATH Classification

Domain Context

CATH Clusters

Superfamily succinate dehydrogenase protein domain
Functional Family Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

Enzyme Information

1.3.5.1
Succinate dehydrogenase (quinone).
based on mapping to UniProt Q9YHT1
Succinate + a quinone = fumarate + a quinol.
-!- The enzyme is found in the inner mitochondrial membrane in eukaryotes and the plasma membrane of many aerobic or facultative bacteria. -!- It catalyzes succinate oxidation in the citric acid cycle and transfers the electrons to quinones in the membrane, thus constituting a part of the aerobic respiratory chain (known as complex II). -!- In vivo the enzyme uses the quinone found in the organism - eukaryotic enzymes utilize ubiquinone, bacterial enzymes utilize ubiquinone or menaquinone, and archaebacterial enzymes from the Sulfolobus genus use caldariellaquinone. -!- Cf. EC 1.3.5.4.

UniProtKB Entries (1)

Q9YHT1
SDHA_CHICK
Gallus gallus
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

PDB Structure

PDB 2H88
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystallographic studies of the binding of ligands to the dicarboxylate site of Complex II, and the identity of the ligand in the
Huang, L.S., Shen, J.T., Wang, A.C., Berry, E.A.
Biochim.Biophys.Acta