CATH Domain 2h5sA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.710	Beta-lactamase
	3.40.710.10	DD-peptidase/beta-lactamase superfamily

Domain Context

CATH Clusters

Superfamily	DD-peptidase/beta-lactamase superfamily
Functional Family

Enzyme Information

3.5.2.6

Beta-lactamase.

based on mapping to UniProt P0AD64

A beta-lactam + H(2)O = a substituted beta-amino acid.

-!- Zinc is only requires in class-B enzymes. -!- A group of enzymes of varying specificity hydrolyzing beta-lactams; some act more rapidly on penicillins, some more rapidly on cephalosporins. -!- Formerly EC 3.5.2.8.

UniProtKB Entries (1)

P0AD64

BLA1_KLEPN

Klebsiella pneumoniae

Beta-lactamase SHV-1

PDB Structure

PDB	2H5S
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Rational Design of a beta-Lactamase Inhibitor Achieved via Stabilization of the trans-Enamine Intermediate: 1.28 A Crystal Structure of wt SHV-1 Complex with a Penam Sulfone. Padayatti, P.S., Sheri, A., Totir, M.A., Helfand, M.S., Carey, M.P., Anderson, V.E., Carey, P.R., Bethel, C.R., Bonomo, R.A., Buynak, J.D., van den Akker, F. J.Am.Chem.Soc.