CATH Classification

CATH Clusters

Superfamily Alpha carbonic anhydrase
Functional Family Alpha carbonic anhydrase 3

Enzyme Information

4.2.1.1
Carbonic anhydrase.
based on mapping to UniProt P00918
H(2)CO(3) = CO(2) + H(2)O.
-!- The enzyme catalyzes the reversible hydration of gaseous CO(2) to carbonic acid, which spontaneously converts to hydrogencarbonate under neutral pH. -!- It is widespread and found in archaea, bacteria, and eukaryotes. -!- Three distinct classes exist, and appear to have evolved independently.

UniProtKB Entries (1)

P00918
CAH2_HUMAN
Homo sapiens
Carbonic anhydrase 2

PDB Structure

PDB 2H4N
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Histidine --> carboxamide ligand substitutions in the zinc binding site of carbonic anhydrase II alter metal coordination geometry but retain catalytic activity.
Lesburg, C.A., Huang, C., Christianson, D.W., Fierke, C.A.
Biochemistry