CATH Classification

Domain Context

CATH Clusters

Superfamily Aspartate Aminotransferase, domain 1
Functional Family 8-amino-7-oxononanoate synthase

Enzyme Information

2.3.1.47
8-amino-7-oxononanoate synthase.
based on mapping to UniProt P12998
Pimeloyl-[acyl-carrier protein] + L-alanine = 8-amino-7-oxononanoate + CO(2) + holo-[acyl-carrier protein].
-!- The enzyme catalyzes the decarboxylative condensation of L-alanine and pimeloyl-[acyl-carrier protein], a key step in the pathway for biotin biosynthesis. -!- Pimeloyl-CoA can be used with lower efficiency.

UniProtKB Entries (1)

P12998
BIOF_ECOLI
Escherichia coli K-12
8-amino-7-oxononanoate synthase

PDB Structure

PDB 2G6W
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Suicide inhibition of alpha-oxamine synthases: structures of the covalent adducts of 8-amino-7-oxononanoate synthase with trifluoroalanine.
Alexeev, D., Baxter, R.L., Campopiano, D.J., Kerbarh, O., Sawyer, L., Tomczyk, N., Watt, R., Webster, S.P.
Org.Biomol.Chem.