CATH Classification

Domain Context

CATH Clusters

Superfamily Alpha carbonic anhydrase
Functional Family Carbonic anhydrase 2

Enzyme Information

4.2.1.1
Carbonic anhydrase.
based on mapping to UniProt P00915
H(2)CO(3) = CO(2) + H(2)O.
-!- The enzyme catalyzes the reversible hydration of gaseous CO(2) to carbonic acid, which spontaneously converts to hydrogencarbonate under neutral pH. -!- It is widespread and found in archaea, bacteria, and eukaryotes. -!- Three distinct classes exist, and appear to have evolved independently.

UniProtKB Entries (1)

P00915
CAH1_HUMAN
Homo sapiens
Carbonic anhydrase 1

PDB Structure

PDB 2FW4
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Carbonic anhydrase activators: The first X-ray crystallographic study of an adduct of isoform I.
Temperini, C., Scozzafava, A., Supuran, C.T.
Bioorg.Med.Chem.Lett.