CATH Classification

Domain Context

CATH Clusters

Superfamily Phospholipase A2 domain
Functional Family Basic phospholipase A2 homolog

Enzyme Information

3.1.1.4
Phospholipase A(2).
based on mapping to UniProt P59071
Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylate.
-!- Also acts on phosphatidylethanolamine, choline plasmalogen and phosphatides, removing the fatty acid attached to the 2-position.

UniProtKB Entries (1)

P59071
PA2B8_DABRR
Daboia russelii
Basic phospholipase A2 VRV-PL-VIIIa

PDB Structure

PDB 2FNX
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Design of Specific Peptide Inhibitors of Phospholipase A2 (PLA2): Crystal Structure of the Complex of PLA2 with a Highly Potent Peptide Val-Ile-Ala-Lys at 2.7A Resolution
Singh, N., Srivastava, P., Sharma, S., Dey, S., Singh, T.P.
To be Published