CATH Classification

Domain Context

CATH Clusters

Superfamily Type I PLP-dependent aspartate aminotransferase-like (Major domain)
Functional Family UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine transaminase

Enzyme Information

2.6.1.92
UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine transaminase.
based on mapping to UniProt O25130
UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine + 2-oxoglutarate = UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose + L-glutamate.
-!- The enzyme transfers the primary amino group of L-glutamate to C-4'' of UDP-4-dehydro sugars, forming a C-N bond in a stereo configuration opposite to that of UDP. -!- The enzyme from the bacterium Bacillus cereus has been shown to act on UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose, UDP-beta- L-threo-pentapyranos-4-ulose, UDP-4-dehydro-6-deoxy-D-glucose, and UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose. -!- Cf. EC 2.6.1.34, which catalyzes a similar reaction, but forms the C-N bond in the same stereo configuration as that of UDP.

UniProtKB Entries (1)

O25130
PSEC_HELPY
Helicobacter pylori 26695
UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine transaminase

PDB Structure

PDB 2FN6
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structural and Functional Characterization of PseC, an Aminotransferase Involved in the Biosynthesis of Pseudaminic Acid, an Essential Flagellar Modification in Helicobacter pylori
Schoenhofen, I.C., Lunin, V.V., Julien, J.P., Li, Y., Ajamian, E., Matte, A., Cygler, M., Brisson, J.R., Aubry, A., Logan, S.M., Bhatia, S., Wakarchuk, W.W., Young, N.M.
J.Biol.Chem.