CATH Classification

Domain Context

CATH Clusters

Superfamily 3.40.190.80
Functional Family Fructose-1,6-bisphosphatase class 1

Enzyme Information

3.1.3.11
Fructose-bisphosphatase.
based on mapping to UniProt P09467
D-fructose 1,6-bisphosphate + H(2)O = D-fructose 6-phosphate + phosphate.
-!- The animal enzyme also acts on sedoheptulose 1,7-bisphosphate.

UniProtKB Entries (1)

P09467
F16P1_HUMAN
Homo sapiens
Fructose-1,6-bisphosphatase 1

PDB Structure

PDB 2FHY
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Benzoxazole benzenesulfonamides are novel allosteric inhibitors of fructose-1,6-bisphosphatase with a distinct binding mode.
von Geldern, T.W., Lai, C., Gum, R.J., Daly, M., Sun, C., Fry, E.H., Abad-Zapatero, C.
Bioorg.Med.Chem.Lett.