CATH Classification

Domain Context

CATH Clusters

Superfamily 1.20.1050.10
Functional Family Glutathione S-transferase 2

Enzyme Information

2.5.1.18
Glutathione transferase.
based on mapping to UniProt P56598
RX + glutathione = HX + R-S-glutathione.
-!- A group of enzymes of broad specificity. -!- R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group. -!- Also catalyzes the addition of aliphatic epoxides and arene oxides to glutathione, the reduction of polyol nitrate by glutathione to polyol and nitrile, certain isomerization reactions and disulfide interchange. -!- Formerly EC 1.8.6.1, EC 2.5.1.12, EC 2.5.1.13, EC 2.5.1.14 and EC 4.4.1.7.

UniProtKB Entries (1)

P56598
GST29_FASHE
Fasciola hepatica
Glutathione S-transferase class-mu 26 kDa isozyme 1

PDB Structure

PDB 2FHE
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystallization, structural determination and analysis of a novel parasite vaccine candidate: Fasciola hepatica glutathione S-transferase.
Rossjohn, J., Feil, S.C., Wilce, M.C., Sexton, J.L., Spithill, T.W., Parker, M.W.
J.Mol.Biol.