CATH Classification

Domain Context

CATH Clusters

Superfamily Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain
Functional Family Mitochondrial succinate dehydrogenase flavoprotein subunit

Enzyme Information

1.3.5.1
Succinate dehydrogenase (quinone).
based on mapping to UniProt Q9YHT1
Succinate + a quinone = fumarate + a quinol.
-!- The enzyme is found in the inner mitochondrial membrane in eukaryotes and the plasma membrane of many aerobic or facultative bacteria. -!- It catalyzes succinate oxidation in the citric acid cycle and transfers the electrons to quinones in the membrane, thus constituting a part of the aerobic respiratory chain (known as complex II). -!- In vivo the enzyme uses the quinone found in the organism - eukaryotic enzymes utilize ubiquinone, bacterial enzymes utilize ubiquinone or menaquinone, and archaebacterial enzymes from the Sulfolobus genus use caldariellaquinone. -!- Cf. EC 1.3.5.4.

UniProtKB Entries (1)

Q9YHT2
SDHB_CHICK
Gallus gallus
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial

PDB Structure

PDB 2FBW
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
3-nitropropionic acid is a suicide inhibitor of mitochondrial respiration that, upon oxidation by complex II, forms a covalent adduct with a catalytic base arginine in the active site of the enzyme.
Huang, L.S., Sun, G., Cobessi, D., Wang, A.C., Shen, J.T., Tung, E.Y., Anderson, V.E., Berry, E.A.
J.Biol.Chem.