CATH Classification

Domain Context

CATH Clusters

Superfamily 2-enoyl-CoA Hydratase; Chain A, domain 1
Functional Family

Enzyme Information

2.1.3.15
Acetyl-CoA carboxytransferase.
based on mapping to UniProt Q5HF73
[Biotin carboxyl-carrier protein]-N(6)-carboxybiotinyl-L-lysine + acetyl- CoA = [biotin carboxyl-carrier protein]-N(6)-biotinyl-L-lysine + malonyl- CoA.
-!- The enzyme catalyzes the transfer of a carboxyl group carried on a biotinylated biotin carboxyl carrier protein (BCCP) to acetyl-CoA, forming malonyl-CoA. -!- In some organisms this activity is part of a multi-domain polypeptide that includes the carrier protein and EC 6.3.4.14 (see EC 6.4.1.2). -!- Some enzymes can also carboxylate propanonyl-CoA and butanoyl-CoA (Cf. EC 6.4.1.3).

UniProtKB Entries (2)

Q2FG38
ACCA_STAA3
Staphylococcus aureus subsp. aureus USA300
Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha
Q5HF73
ACCD_STAAC
Staphylococcus aureus subsp. aureus COL
Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta

PDB Structure

PDB 2F9I
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
The structure of the carboxyltransferase component of acetyl-coA carboxylase reveals a zinc-binding motif unique to the bacterial enzyme.
Bilder, P., Lightle, S., Bainbridge, G., Ohren, J., Finzel, B., Sun, F., Holley, S., Al-Kassim, L., Spessard, C., Melnick, M., Newcomer, M., Waldrop, G.L.
Biochemistry