CATH Classification

Domain Context

CATH Clusters

Superfamily SH3 Domains
Functional Family 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma

Enzyme Information

3.1.4.11
Phosphoinositide phospholipase C.
based on mapping to UniProt Q8CIH5
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.
-!- These enzymes form some of the cyclic phosphate Ins(cyclic 1,2)P(4,5)P(2) as well as Ins(1,4,5)P(3). -!- They show activity toward phosphatidylinositol, i.e., the activity of EC 4.6.1.13 in vitro at high calcium concentration.

UniProtKB Entries (1)

Q8CIH5
PLCG2_MOUSE
Mus musculus
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2

PDB Structure

PDB 2EQI
External Links
Method SOLUTION NMR
Organism
Primary Citation
Solution structure of the SH3 domain from Phospholipase C, gamma 2
Qin, X.R., Nagashima, T., Hayashi, F., Yokoyama, S.
To be Published