CATH Classification

Domain Context

CATH Clusters

Superfamily 3.30.60.20
Functional Family Protein kinase C alpha

Enzyme Information

2.7.11.13
Protein kinase C.
based on mapping to UniProt P17252
ATP + a protein = ADP + a phosphoprotein.
-!- A family of serine- and threonine-specific protein kinases that depend on lipids for activity. -!- They can be activated by calcium but have a requirement for the second messenger diacylglycerol. -!- Members of this group of enzymes phosphorylate a wide variety of protein targets and are known to be involved in diverse cell- signaling pathways. -!- Members of the protein kinase C family also serve as major receptors for phorbol esters, a class of tumor promoters. -!- Formerly EC 2.7.1.37.

UniProtKB Entries (1)

P17252
KPCA_HUMAN
Homo sapiens
Protein kinase C alpha type

PDB Structure

PDB 2ELI
External Links
Method SOLUTION NMR
Organism
Primary Citation
Solution structure of the second Phorbol esters/diacylglycerol binding domain of human Protein kinase C alpha type
Tochio, N., Koshiba, S., Saito, K., Tomizawa, T., Watanabe, S., Harada, T., Kigawa, T., Yokoyama, S.
To be Published