CATH Classification

Domain Context

CATH Clusters

Superfamily 3.20.20.220
Functional Family

Enzyme Information

1.5.5.2
Proline dehydrogenase.
based on mapping to UniProt Q72IB8
L-proline + a quinone = (S)-1-pyrroline-5-carboxylate + a quinol.
-!- The electrons from L-proline are transferred to the FAD cofactor, and from there to a quinone acceptor. -!- In many organisms, ranging from bacteria to mammals, proline is oxidized to glutamate in a two-step process involving this enzyme and EC 1.2.1.88. -!- Both activities are carried out by the same enzyme in enterobacteria. -!- Formerly EC 1.5.99.8.

UniProtKB Entries (1)

Q72IB8
PRODH_THET2
Thermus thermophilus HB27
Proline dehydrogenase

PDB Structure

PDB 2EKG
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural basis for the inactivation of Thermus thermophilus proline dehydrogenase by N-propargylglycine
White, T.A., Johnson, W.H., Whitman, C.P., Tanner, J.J.
Biochemistry