CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphorylase Kinase; domain 1
Functional Family Serine/threonine-protein kinase Chk1

Enzyme Information

2.7.11.1
Non-specific serine/threonine protein kinase.
based on mapping to UniProt O14757
ATP + a protein = ADP + a phosphoprotein.
-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.

UniProtKB Entries (1)

O14757
CHK1_HUMAN
Homo sapiens
Serine/threonine-protein kinase Chk1

PDB Structure

PDB 2E9N
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Discovery of 1,4-dihydroindeno[1,2-c]pyrazoles as a novel class of potent and selective checkpoint kinase 1 inhibitors.
Tong, Y., Claiborne, A., Stewart, K.D., Park, C., Kovar, P., Chen, Z., Credo, R.B., Gu, W.Z., Gwaltney, S.L., Judge, R.A., Zhang, H., Rosenberg, S.H., Sham, H.L., Sowin, T.J., Lin, N.H.
Bioorg.Med.Chem.