CATH Classification

Domain Context

CATH Clusters

Superfamily Leucine Dehydrogenase, chain A, domain 1
Functional Family

Enzyme Information

1.1.1.25
Shikimate dehydrogenase.
based on mapping to UniProt Q5SJF8
Shikimate + NADP(+) = 3-dehydroshikimate + NADPH.
-!- NAD(+) cannot replace NADP(+). -!- In higher organisms, this enzyme forms part of a multienzyme complex with EC 4.2.1.10.

UniProtKB Entries (1)

Q5SJF8
AROE_THET8
Thermus thermophilus HB8
Shikimate dehydrogenase (NADP(+))

PDB Structure

PDB 2CY0
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal Structures of Shikimate Dehydrogenase AroE from Thermus thermophilus HB8 and its Cofactor and Substrate Complexes: Insights into the Enzymatic Mechanism
Bagautdinov, B., Kunishima, N.
J.Mol.Biol.