CATH Classification

Domain Context

CATH Clusters

Superfamily Isoleucyl-tRNA Synthetase; Domain 1
Functional Family Methionine-tRNA ligase

Enzyme Information

6.1.1.10
Methionine--tRNA ligase.
based on mapping to UniProt O67298
ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl- tRNA(Met).
-!- In those organisms producing N-formylmethionyl-tRNA(fMet) for translation initiation, this enzyme also recognizes the initiator tRNA(fMet) and catalyzes the formation of L-methionyl-tRNA(fMet), the substrate for EC 2.1.2.9.

UniProtKB Entries (1)

O67298
SYM_AQUAE
Aquifex aeolicus VF5
Methionine--tRNA ligase

PDB Structure

PDB 2CT8
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structural basis for anticodon recognition by methionyl-tRNA synthetase.
Nakanishi, K., Ogiso, Y., Nakama, T., Fukai, S., Nureki, O.
Nat.Struct.Mol.Biol.