CATH Classification

Domain Context

CATH Clusters

Superfamily Trypsin-like serine proteases
Functional Family

Enzyme Information

3.4.21.21
Coagulation factor VIIa.
based on mapping to UniProt P08709
Selective cleavage of Arg-|-Ile bond in factor X to form factor Xa.
-!- Formed from the precursor factor VII. -!- The cattle enzyme is more readily inhibited by diisopropyl fluorophosphate than the human. -!- Belongs to peptidase family S1.

UniProtKB Entries (1)

P13726
TF_HUMAN
Homo sapiens
Tissue factor

PDB Structure

PDB 2C4F
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The Discovery of Fluoropyridine-Based Inhibitors of the Factor Viia/Tf Complex--Part 2
Kohrt, J.T., Filipski, K.J., Cody, W.L., Cai, C., Dudley, D.A., Huis, C.A.V., Willardsen, J.A., Narasimhan, L.S., Zhang, E., Rapundalo, S.T., Saiya-Cork, K., Leadley, R.J., Edmunds, J.J.
Bioorg.Med.Chem.Lett.