CATH Classification

Domain Context

CATH Clusters

Superfamily NAD(P)-binding Rossmann-like Domain
Functional Family Short-chain dehydrogenase reductase

Enzyme Information

1.1.1.331
Secoisolariciresinol dehydrogenase.
based on mapping to UniProt Q94KL8
(-)-secoisolariciresinol + 2 NAD(+) = (-)-matairesinol + 2 NADH.
-!- Isolated from the plants Forsythia intermedia and Podophyllum peltatum. -!- An intermediate lactol is detected in vitro.

UniProtKB Entries (1)

Q94KL8
SILD_PODPE
Podophyllum peltatum
Secoisolariciresinol dehydrogenase

PDB Structure

PDB 2BGL
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal Structures of Apo-Form and Binary/Ternary Complexes of Podophyllum Secoisolariciresinol Dehydrogenase, an Enzyme Involved in Formation of Health-Protecting and Plant Defense Lignans
Youn, B., Moinuddin, S.G., Davin, L.B., Lewis, N.G., Kang, C.
J.Biol.Chem.