CATH Classification

Domain Context

CATH Clusters

Superfamily Vaccinia Virus protein VP39
Functional Family Glycine N-methyltransferase

Enzyme Information

2.1.1.20
Glycine N-methyltransferase.
based on mapping to UniProt Q14749
S-adenosyl-L-methionine + glycine = S-adenosyl-L-homocysteine + sarcosine.
-!- Thought to play an important role in the regulation of methyl group metabolism in the liver and pancreas by regulating the ratio between S-adenosyl-L-methionine and S-adenosyl-L-homocysteine. -!- Inhibited by 5-methyltetrahydrofolate pentaglutamate. -!- Sarcosine, which has no physiological role, is converted back into glycine by the action of EC 1.5.8.3.

UniProtKB Entries (1)

Q14749
GNMT_HUMAN
Homo sapiens
Glycine N-methyltransferase

PDB Structure

PDB 2AZT
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Destabilization of human glycine N-methyltransferase by H176N mutation.
Luka, Z., Pakhomova, S., Luka, Y., Newcomer, M.E., Wagner, C.
Protein Sci.