CATH Classification

Domain Context

CATH Clusters

Superfamily 3.10.50.40
Functional Family

Enzyme Information

5.2.1.8
Peptidylprolyl isomerase.
based on mapping to UniProt Q14318
Peptidylproline (omega=180) = peptidylproline (omega=0).
-!- The first type of this enzyme found proved to be the protein cyclophilin, which binds the immunosuppressant cyclosporin A. -!- Other distinct families of the enzyme exist, one being FK-506 binding proteins (FKBP) and another that includes parvulin from Escherichia coli. -!- The three families are structurally unrelated and can be distinguished by being inhibited by cyclosporin A, FK-506 and 5-hydroxy-1,4-naphthoquinone, respectively.

UniProtKB Entries (1)

Q14318
FKBP8_HUMAN
Homo sapiens
Peptidyl-prolyl cis-trans isomerase FKBP8

PDB Structure

PDB 2AWG
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structure of the human FK-506 binding protein 8
Walker, J.R., Davis, T., Newman, E.M., Finerty, P., Mackenzie, F., Weigelt, J., Sundstrom, M., Arrowsmith, C., Edwards, A., Bochkarev, A., Dhe-Paganon, S.
To be Published