CATH Classification

Domain Context

CATH Clusters

Superfamily 2.40.50.100
Functional Family DNA-directed RNA polymerase subunit beta

Enzyme Information

2.7.7.6
DNA-directed RNA polymerase.
based on mapping to UniProt P0A8T7
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
-!- Catalyzes DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. -!- Can initiate a chain de novo. -!- In eukaryotes three forms of the enzyme have been distinguished on the basis of sensitivity of alpha-amanitin, and the type of RNA synthesized. -!- See also EC 2.7.7.19 and EC 2.7.7.48.

UniProtKB Entries (1)

P0A8T7
RPOC_ECOLI
Escherichia coli K-12
DNA-directed RNA polymerase subunit beta'

PDB Structure

PDB 2AUK
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structure and Function of Lineage-specific Sequence Insertions in the Bacterial RNA Polymerase beta' Subunit
Chlenov, M., Masuda, S., Murakami, K.S., Nikiforov, V., Darst, S.A., Mustaev, A.
J.Mol.Biol.