CATH Classification

Domain Context

CATH Clusters

Superfamily Trypsin-like serine proteases
Functional Family Transmembrane protease serine

Enzyme Information

3.4.21.27
Coagulation factor XIa.
based on mapping to UniProt P03951
Selective cleavage of Arg-|-Ala and Arg-|-Val bonds in factor IX to form factor IXa.
-!- The proenzyme XI is activated by EC 3.4.21.38. -!- Belongs to peptidase family S1.

UniProtKB Entries (1)

P03951
FA11_HUMAN
Homo sapiens
Coagulation factor XI

PDB Structure

PDB 1ZTL
External Links
Method X-RAY DIFFRACTION
Organism Pichia
Primary Citation
Pyrimidinone Inhibitors of a Thrombolytic Protease
Nagafuji, P., Jin, L., Rynkiewicz, M., Quinn, J., Bibbins, F., Meyers, H., Babine, R., Strickler, J.E., Abdel-Meguid, S.S.
To be Published