CATH Classification

Domain Context

CATH Clusters

Superfamily 4.10.80.70
Functional Family

Enzyme Information

3.5.4.19
Phosphoribosyl-AMP cyclohydrolase.
based on mapping to UniProt O26347
1-(5-phospho-beta-D-ribosyl)-AMP + H(2)O = 1-(5-phospho-beta-D-ribosyl)- 5-((5-phospho-beta-D-ribosylamino)methylideneamino)imidazole-4- carboxamide.
-!- The Neurospora crassa enzyme also catalyzes the reactions of EC 1.1.1.23 and EC 3.6.1.31.

UniProtKB Entries (1)

O26347
HIS3_METTH
Methanothermobacter thermautotrophicus str. Delta H
Phosphoribosyl-AMP cyclohydrolase

PDB Structure

PDB 1ZPS
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal Structure of Methanobacterium thermoautotrophicum Phosphoribosyl-AMP Cyclohydrolase HisI.
Sivaraman, J., Myers, R.S., Boju, L., Sulea, T., Cygler, M., Davisson, V.J., Schrag, J.D.
Biochemistry