CATH Classification

Domain Context

CATH Clusters

Superfamily Anthrax toxin, edema factor, central domain
Functional Family

Enzyme Information

4.6.1.1
Adenylate cyclase.
based on mapping to UniProt P0DKX7
ATP = 3',5'-cyclic AMP + diphosphate.
-!- Also acts on dATP to form 3',5'-cyclic dAMP. -!- Requires pyruvate. -!- Activated by NAD(+) in presence of EC 2.4.2.31.

UniProtKB Entries (2)

P0DP25
CALM3_HUMAN
Homo sapiens
Calmodulin-3
P0DKX7
CYAA_BORPE
Bordetella pertussis Tohama I
Bifunctional hemolysin/adenylate cyclase

PDB Structure

PDB 1ZOT
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structural basis for the interaction of Bordetella pertussis adenylyl cyclase toxin with calmodulin.
Guo, Q., Shen, Y., Lee, Y.S., Gibbs, C.S., Mrksich, M., Tang, W.J.
Embo J.