CATH Classification

Domain Context

CATH Clusters

Superfamily Transferase(Phosphotransferase) domain 1
Functional Family

Enzyme Information

2.7.11.1
Non-specific serine/threonine protein kinase.
based on mapping to UniProt O08679
ATP + a protein = ADP + a phosphoprotein.
-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.
2.7.11.26
[Tau protein] kinase.
based on mapping to UniProt O08679
ATP + [tau protein] = ADP + [tau protein] phosphate.
-!- Activated by tubulin. -!- Involved in the formation of paired helical filaments, which are the main fibrous component of all fibrillary lesions in brain and are associated with Alzheimer's disease. -!- Formerly EC 2.7.1.135.

UniProtKB Entries (1)

O08679
MARK2_RAT
Rattus norvegicus
Serine/threonine-protein kinase MARK2

PDB Structure

PDB 1ZMW
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structure of the catalytic and ubiquitin-associated domains of the protein kinase MARK/Par-1.
Panneerselvam, S., Marx, A., Mandelkow, E.M., Mandelkow, E.
Structure