CATH Classification

Domain Context

CATH Clusters

Superfamily PUA domain
Functional Family

Enzyme Information

5.4.99.25
tRNA pseudouridine(55) synthase.
based on mapping to UniProt Q9WZW0
tRNA uridine(55) = tRNA pseudouridine(55).
-!- Pseudourine synthase TruB from Escherichia coli specifically modifies uridine(55) in tRNA molecules. -!- The bifunctional archaeal enzyme also catalyzes the pseudouridylation of uridine(54). -!- It is not known whether the enzyme from Escherichia coli can also act on position 54 in vitro, since this position is occupied in E.coli tRNAs by thymine.

UniProtKB Entries (1)

Q9WZW0
TRUB_THEMA
Thermotoga maritima MSB8
TRNA pseudouridine synthase B

PDB Structure

PDB 1ZE2
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Conformational change of pseudouridine 55 synthase upon its association with RNA substrate
Phannachet, K., Huang, R.H.
Nucleic Acids Res.