CATH Classification

Domain Context

CATH Clusters

Superfamily Trypsin-like serine proteases
Functional Family Prothrombin

Enzyme Information

3.4.21.5
Thrombin.
based on mapping to UniProt P00734
Selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B.
-!- More selective than trypsin and plasmin. -!- Belongs to peptidase family S1. -!- Formerly EC 3.4.4.13.

UniProtKB Entries (2)

P00734
THRB_HUMAN
Homo sapiens
Prothrombin
P28511
HIR3C_HIRME
Hirudo medicinalis
Hirudin-3B'

PDB Structure

PDB 1Z71
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
P(2) pyridine N-oxide thrombin inhibitors: a novel peptidomimetic scaffold
Nantermet, P.G., Burgey, C.S., Robinson, K.A., Pellicore, J.M., Newton, C.L., Deng, J.Z., Selnick, H.G., Lewis, S.D., Lucas, B.J., Krueger, J.A., Miller-Stein, C., White, R.B., Wong, B., McMasters, D.R., Wallace, A.A., Lynch Jr., J.J., Yan, Y., Chen, Z., Kuo, L., Gardell, S.J., Shafer, J.A., Vacca, J.P., Lyle, T.A.
BIOORG.MED.CHEM.LETT.