1 keywords

CATH Domain 1ydnA00

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.20 Alpha-Beta Barrel
Topology 3.20.20 TIM Barrel
Homologous Superfamily 3.20.20.70 Aldolase class I

Domain Context

CATH Clusters

Superfamily Aldolase class I
Functional Family Hydroxymethylglutaryl-CoA lyase

Enzyme Information

UniProtKB Entries (1)

Q8YEF2
Q8YEF2_BRUME
Brucella melitensis bv. 1 str. 16M
Hydroxymethylglutaryl-CoA lyase

PDB Structure

PDB 1YDN
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structures of two bacterial 3-hydroxy-3-methylglutaryl-CoA lyases suggest a common catalytic mechanism among a family of TIM barrel metalloenzymes cleaving carbon-carbon bonds.
Forouhar, F., Hussain, M., Farid, R., Benach, J., Abashidze, M., Edstrom, W.C., Vorobiev, S.M., Xiao, R., Acton, T.B., Fu, Z., Kim, J.J., Miziorko, H.M., Montelione, G.T., Hunt, J.F.
J.Biol.Chem.