CATH Classification

Domain Context

CATH Clusters

Superfamily Ribonuclease H-like superfamily/Ribonuclease H
Functional Family Three prime repair exonuclease 1

Enzyme Information

3.1.11.2
Exodeoxyribonuclease III.
based on mapping to UniProt Q9BQ50
Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates.
-!- Preference for double-stranded DNA. -!- Has endonucleolytic activity near apurinic sites on DNA. -!- Similar enzyme: Haemophilus influenzae exonuclease. -!- Formerly EC 3.1.4.27.

UniProtKB Entries (1)

Q9BQ50
TREX2_HUMAN
Homo sapiens
Three prime repair exonuclease 2

PDB Structure

PDB 1Y97
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
The Human TREX2 3' -> 5'-Exonuclease Structure Suggests a Mechanism for Efficient Nonprocessive DNA Catalysis.
Perrino, F.W., Harvey, S., McMillin, S., Hollis, T.
J.Biol.Chem.