CATH Classification

Domain Context

CATH Clusters

Superfamily Nucleotide cyclase
Functional Family pH-sensitive adenylate cyclase Rv1264

Enzyme Information

4.6.1.1
Adenylate cyclase.
based on mapping to UniProt P9WMU9
ATP = 3',5'-cyclic AMP + diphosphate.
-!- Also acts on dATP to form 3',5'-cyclic dAMP. -!- Requires pyruvate. -!- Activated by NAD(+) in presence of EC 2.4.2.31.

UniProtKB Entries (1)

P9WMU9
Y1264_MYCTU
Mycobacterium tuberculosis H37Rv
PH-sensitive adenylate cyclase Rv1264

PDB Structure

PDB 1Y11
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
The structure of a pH-sensing mycobacterial adenylyl cyclase holoenzyme
Tews, I., Findeisen, F., Sinning, I., Schultz, A., Schultz, J.E., Linder, J.U.
Science